William married Sophia Fisk on 5 Sep 1842 in Cuyahoga, Ohio, USA. Sophia (daughter of Daniel J. Fisk and Sarah D. Bowen) was born on 9 Mar 1826 in Springfield Township, Summit, Ohio, USA; died on 4 Apr 1891 in Saint Paul, Ramsey, Minnesota, USA. [Group Sheet] [Family Chart]

1. Clementina Sophia Murphy was born on 31 Oct 1843 in Philadelphia, Pennsylvania, USA; died on 14 Dec 1887 in Los Angeles, California, USA.
2. Charles H. Murphy was born on 11 Apr 1845 in Philadelphia, Pennsylvania, USA; died on 8 Jun 1859 in Wilton, Waseca, Minnesota, USA.
3. Sarah Ann Murphy was born on 15 Jun 1847 in Philadelphia, Pennsylvania, USA; died on 11 May 1933 in Winona, Winona, Minnesota, USA.
4. John Fisk Murphy was born on 7 Jan 1850 in Philadelphia, Pennsylvania, USA; died on 21 Mar 1923 in Waseca, Minnesota, USA.
5. William Merton Murphy was born on 21 Jan 1852 in Philadelphia, Pennsylvania, USA; died on 2 Feb 1932 in Saint Paul, Ramsey, Minnesota, USA.
6. Susan Hunter Murphy was born on 4 Sep 1854 in Philadelphia, Philadelphia, Pennsylvania, USA; died on 27 Mar 1931 in Lane, Oregon, USA.
7. Francis Simon Murphy was born on 12 Apr 1857 in Philadelphia, Pennsylvania, USA; died on 16 Jan 1938 in Houghton, Houghton, Michigan, USA.