Issac married Anna Woodward on 1 Jun 1797 in Hubbardston, Worcester, Massachusetts, USA. Anna (daughter of Elisha Woodward and Ann Murdock) was born on 3 May 1778 in Hubbardston, Worcester, Massachusetts, USA; died on 5 Jun 1816. [Group Sheet] [Family Chart]

1. Elisha Whittemore was born in Hubbardston, Worcester, Massachusetts, USA.
2. Almira Elizabeth Whittemore was born on 20 Aug 1800 in Hubbardston, Worcester, Massachusetts, USA; died on 25 Jul 1833 in Templeton, Worcester, Massachusetts, USA; was buried in Hubbardston, Worcester, Massachusetts, USA.
3. Eliza Whittemore was born in 1802 in Hubbardston, Worcester, Massachusetts, USA.
4. Elvira Whittemore was born about 1803 in Westminster, Worcester, Massachusetts, USA; died before 1833.
5. William Whittemore was born on 22 Sep 1809 in Hubbardston, Worcester, Massachusetts, USA; died in Jul 1887.