Isaac married Elizabeth Fuller on 31 Dec 1702 in Cambridge, Middlesex, Massachusetts, USA. Elizabeth (daughter of Joshua Fuller and Elizabeth Ward) was born on 22 Feb 1680 in Cambridge Village, Middlesex, Massachusetts, USA; died on 29 Jun 1761 in Weston, Middlesex, Massachusetts, USA. [Group Sheet] [Family Chart]

1. Isaac Shepard, Jr. was born on 19 Jan 1704 in Watertown, Middlesex, Massachusetts, USA; died on 6 Jan 1778 in New Marlborough,Berkshire,Massachusetts, USA.
2. Joshua Shepard was born on 3 Apr 1705 in Watertown, Middlesex, Massachusetts, USA; died on 7 Nov 1730 in Needham, Norfolk, Massachusetts, USA.
3. Elizabeth Shepard was born on 13 May 1707 in Norton, Bristol, Massachusetts, USA; was christened on 15 Jun 1707 in Wrentham,Norfolk,Massachusetts, USA; died on 18 Nov 1760 in Hardwick,Worcester,Massachusetts, USA.
4. Jonathan Shepard, Sr. was born on 6 Aug 1709 in Norton, Bristol, Massachusetts, USA; was christened on 23 Oct 1709 in Norton, Bristol, Massachusetts, USA; died on 26 Mar 1798 in Windsor, Windsor, Vermont, USA; was buried in Old South Cemetery,Windsor, Windsor, Vermont, USA.
5. Hannah Shepard was born on 3 Aug 1711 in Norton, Bristol, Massachusetts, USA; was christened on 1 Jun 1712 in Wrentham,Norfolk,Massachusetts, USA; died in 1752 in Weston, Middlesex, Massachusetts, USA.
6. Reverend Nathaniel Shepard, Sr. was born on 13 Feb 1713 in Norton, Bristol, Massachusetts, USA; died on 14 Apr 1752 in Attleborough, Bristol, Massachusetts, USA; was buried in Woodcock Cemetery, Attleborough, Bristol, Massachusetts, USA.
7. Sarah Shepard was born on 2 Mar 1715 in Norton, Bristol, Massachusetts, USA; died on 11 Jul 1756 in Weston, Middlesex, Massachusetts, USA.
8. Noah Shepard was born on 22 Feb 1717 in Norton, Bristol, Massachusetts, USA; was christened in Oct 1717 in Norton, Bristol, Massachusetts, USA; died in 1809 in Enfield, Hartford, Connecticut, USA.
9. Jacob Shepard was born on 12 Dec 1721 in Norton, Bristol, Massachusetts, USA; died on 30 May 1747 in Canada.