Isaac married Aaltje Harzen on 26 Feb 1777. Aaltje (daughter of Japik Harzen, Jacob and Marytje Pruyn) was christened on 12 Aug 1750 in Albany, Albany, New York, USA. [Group Sheet] [Family Chart]

1. Catherine Washington Varian was born on 4 Apr 1778 in New York City, , New York, USA.
2. George Varian was born on 21 Mar 1779 in New York City, , New York, USA; was christened on 9 May 1784 in New York City, , New York, USA.
3. Jacob Harsin Varian was born on 8 Sep 1781 in New York City, , New York, USA; was christened on 9 May 1784 in New York City, , New York, USA; died on 24 Oct 1845.
4. Richard Varian was born on 2 Sep 1783 in New York City, , New York, USA; was christened on 9 May 1784 in New York City, , New York, USA; died on 5 Dec 1842.