Joseph married Mary Weston Bixby on 4 Jun 1846. Mary (daughter of Rufus Bixby and Betsey Weston) was born on 19 Sep 1820 in Norridgewock,Somerset,Maine, USA; died on 5 Nov 1867; was buried in Riverside Cemetery,Farmington, Franklin, Maine, USA. [Group Sheet] [Family Chart]

1. Gussie Elizabeth Hopkins was born on 28 Dec 1848; died on 18 Jun 1865; was buried in Riverside Cemetery,Farmington, Franklin, Maine, USA.
2. Dr. William Bixby Hopkins, Sr. was born on 15 Apr 1854 in Norridgewock,Somerset,Maine, USA; died on 9 Feb 1918 in Cumberland,Barron,Wisconsin, USA; was buried in Lakeside Cemetery,Cumberland,Barron,Wisconsin, USA.