John married Elizabeth Hadley on 12 May 1818 in Clermont, Ohio, USA. Elizabeth (daughter of Ebenezer Hadley, Jr. and Jemima Fuller) was born on 24 May 1797 in Lawersville, Schoharie, New York, USA; was christened on 27 Jul 1797 in German Reformed Church, New Rhinebeck-Cobleskill, Schoharie, New York, USA; died in Jan 1835 in Clermont, Ohio, USA. [Group Sheet] [Family Chart]

1. Martha Isham was born on 16 Feb 1815 in Colchester, New London, Connecticut, USA.
2. Mary Isham was born on 16 Feb 1815 in Colchester, New London, Connecticut, USA.
3. John Hayes Isham was born in 1830 in Clermont, Ohio, USA.
4. James A. Isham was born on 16 Sep 1834 in Batavia, Clermont, Ohio, USA; died on 20 May 1911 in Oglesby, LaSalle, Illinois, USA; was buried in Oak Hill Cemetery, Utica, LaSalle, Illinois, USA.