Miles married Mary W. Fuller on 3 May 1818 in Watertown, Middlesex, Massachusetts, USA. Mary (daughter of Oliver Fuller, Sr. and Ruth Wyman) was born on 27 Apr 1794 in Watertown, Middlesex, Massachusetts, USA; died on 24 Nov 1863 in Boston, Suffolk, Massachusetts, USA. [Group Sheet] [Family Chart]

1. Mary L. Sprague was born about 1819 in Watertown, Middlesex, Massachusetts, USA; died on 3 Apr 1896 in Watertown, Middlesex, Massachusetts, USA.
2. Lucy Locke Sprague was born on 16 Oct 1820 in Watertown, Middlesex, Massachusetts, USA; died on 23 Nov 1891 in Watertown, Middlesex, Massachusetts, USA; was buried in Common Street Cemetery, Watertown, Middlesex, Massachusetts, USA.
3. Miles Standish Sprague was born about 1824 in Canton, Norfolk, Massachusetts, USA; died on 11 Feb 1850 in Boston, Suffolk, Massachusetts, USA; was buried in Common Street Cemetery, Watertown, Middlesex, Massachusetts, USA.
4. Samuel C. Sprague was born about 1826 in Watertown, Middlesex, Massachusetts, USA; died on 20 Apr 1866 in Boston, Suffolk, Massachusetts, USA.
5. Sarah Lucretia Sprague was born about Sep 1828 in Watertown, Middlesex, Massachusetts, USA; died on 2 Jun 1881 in Cambridge, Middlesex, Massachusetts, USA.
6. Henry Sprague was born about 1832 in Massachusetts, USA.
7. Daniel W. Sprague was born about 1833; died on 5 Feb 1848 in Boston, Suffolk, Massachusetts, USA; was buried on 8 Feb 1848 in Watertown, Middlesex, Massachusetts, USA.
8. James M. Sprague was born on 13 Apr 1834 in Watertown, Middlesex, Massachusetts, USA; died on 20 Jul 1888 in Somerville, Middlesex, Massachusetts, USA; was buried in Common Street Cemetery, Watertown, Middlesex, Massachusetts, USA.