Samuel married Mary Cornelia Lansdale on 24 Jun 1866 in Waseca, Minnesota, USA. Mary (daughter of Alpheus H. Lansdale and Mary Cordelia Fisk) was born on 18 Aug 1848 in Ohio, USA; died on 10 Sep 1927 in Pendleton, Umatilla, Oregon, USA. [Group Sheet] [Family Chart]

1. Mary Frances Isaac was born on 27 Mar 1868 in Minnesota, USA; died on 9 Mar 1922 in Los Angeles, Los Angeles, California, USA.
2. Anna Marguetta Isaac was born on 29 Dec 1869 in Dry Creek, Benton, Oregon, USA; died on 3 Mar 1954.
3. Agnes Eusebia Isaac was born in 1872; died in 1942.
4. George Ladow Isaac was born in 1876; died in 1876.
5. James Alphus Isaac was born on 3 Nov 1877 in Pendleton, Umatilla, Oregon, USA; died on 6 Mar 1953 in Pendleton, Umatilla, Oregon, USA.
6. William Hiatt Isaac was born in 1880; died in 1931.
7. Edith May Isaac was born on 18 Dec 1883 in Umatilla, Oregon, USA; died on 7 Feb 1971.