Winthrop married Lydia Hunting on 25 Jul 1822 in Chelmsford,Middlesex, Massachusetts, USA. Lydia (daughter of Nathan Hunting and Elizabeth Barber) was born on 24 Mar 1802 in Chelmsford, Middlesex, Massachusetts, USA; died on 7 Aug 1867 in Grafton, Worcester, Massachusetts, USA or New Hampshire, USA. [Group Sheet] [Family Chart]

1. Benjamin Franklin Howe
2. William Francis Howe
3. Mary Eliza Howe
4. Alfred Perry Howe
5. Julia Ann Howe was born on 24 Dec 1827 in Tewksbury, Middlesex, Massachusetts, USA; died on 26 Nov 1865 in Grafton, Worcester, Massachusetts, USA .
6. Abby Catherine Howe was born on 18 Dec 1829.
7. Sarah Adaline Howe was born about 1832.
8. George Winthrop Howe was born about 1834.
9. Caroline S. Howe was born about 1836.
10. Lucinda Ellen Howe was born on 10 Feb 1840 in Fitchburg, Worcester, Massachusetts, USA.
11. Alfred Alonzo or Alphonse Howe was born about 1841.
12. Lydia Electa Howe was born about 1844.