Isaac married Mary Brown on 18 May 1760 in Canaan,Litchfield,Connecticut, USA. Mary (daughter of Deacon Samuel Abraham Brown, Sr. and Mercy Patterson) was born on 5 Nov 1742 in Stockbridge, Berkshire, Massachusetts, USA. [Group Sheet] [Family Chart]

1. Lydia Lawrence was born about 1761 in Canaan, Litchfield, Connecticut, USA; died in Sep 1813 in New York, USA.
2. Elijah Lawrence was born on 17 Oct 1763 in Canaan, Litchfield, Connecticut, USA; died on 15 Mar 1809.
3. Samuel Lawrence was born on 19 Nov 1765 in North Canaan, Litchfield, Connecticut, USA; died on 25 Apr 1847; was buried in Saint John's Cemetery, Bromont, Monteregie Region, Quebec, Canada.
4. Isaac Lawrence, III was born on 22 Nov 1767 in Canaan, Litchfield, Connecticut, USA; died on 6 Mar 1869 in West Shefford,Quebec, Canada.
5. Mary Lawrence was born on 4 May 1770 in Canaan, Litchfield, Connecticut, USA; died on 27 Feb 1834.
6. Apame Lawrence was born on 7 Dec 1772 in Canaan, Litchfield, Connecticut, USA.
7. Amme Lawrence was born on 7 Dec 1772 in likely Canaan, Litchfield, Connecticut, USA .
8. Henry Lawrence, Sr. was born on 25 Feb 1778 in Canaan, Litchfield, Connecticut, USA; died on 31 Mar 1864 in Lawrenceville, Estrie Region, Quebec, Canada; was buried in Lawrenceville Methodist Cemetery, Lawrenceville, Estrie Region, Quebec, Canada.
9. Erastus Lawrence was born on 11 Mar 1780 in Canaan, Litchfield, Connecticut, USA; died about 1837.
10. Pamelia Lawrence was born on 17 May 1782 in Canaan, Litchfield, Connecticut, USA.
11. David Lawrence was born on 7 Jun 1785 in Shefford County, Quebec, Canada; died on 2 Jun 1862 in Lawrenceville, Quebec, Canada.